Baig, S.S. orcid.org/0000-0003-1415-8784, Dorney, S., Aziz, M. et al. (5 more authors) (2025) Optimizing non-invasive vagus nerve stimulation for treatment in stroke. Neural Regeneration Research, 20 (12). pp. 3388-3399. ISSN 1673-5374
Abstract
Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke. However, previously published research has only investigated a narrow range of stimulation settings and indications. In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. We further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation, focusing on critical aspects such as stimulation settings, target groups, biomarkers, and integration with rehabilitation interventions.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2024 The Author(s). This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License (http://creativecommons.org/licenses/by-nc-sa/4.0), which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
Keywords: | neuromodulation; neuroplasticity; rehabilitation; stroke; vagal nerve stimulation; vagus nerve stimulation |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Funding Information: | Funder Grant number Efficacy and Mechanism Evaluation programme NIHR133169 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Feb 2025 17:07 |
Last Modified: | 21 Feb 2025 17:07 |
Status: | Published |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Refereed: | Yes |
Identification Number: | 10.4103/nrr.nrr-d-24-00945 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223661 |
Download
Filename: optimizing_non_invasive_vagus_nerve_stimulation.3.pdf
Licence: CC-BY-NC-SA 4.0