Awan, S., Wasay, M. orcid.org/0000-0003-3750-2613, Iqbal, R. et al. (3 more authors) (2025) Predictors of functional outcome at 1 year after stroke: analysis of INTERSTROKE data from Pakistan. Journal of Stroke Medicine. ISSN 2516-6085
Abstract
Background and Objective
Identification of early and long-term outcomes after stroke is important in stroke management strategies. The aim of this study was to analyse predictors of independence and functional outcome at 1 and 12 months post-stroke. Methods This was a prospective study of patients with first stroke who were enrolled between April 2013 and July 2015 from a single-centre tertiary care hospital in Pakistan. Patients were followed up at 1 and 12 months and assessed using the modified Rankin scale (mRs).
Results
A total of 395 patients with acute first strokes were enrolled. Stroke dependency (mRs score 3-5) was higher in our site at 1 month. At 1 month, 137 (34.6%) of the participants were independent (mRs 0-2), 54.1% (n = 214) were dependent (mRs 3-5) and 11.1% (n = 44) died. At 12 months, 86% (n = 303/351) completed the follow-up. Of 303 participants, 35.3% (n = 107) were independent (mRs 0-2), 35.6% (n = 108) were dependent (mRs 3-5) and 29% (n = 88) had died. Forty-eight patients (14%) were lost to follow-up. Overall mortality was 33% (132/395) in 1 year. At 12 months, no comorbidities (OR 3.26; 95% CI: 1.48-7.21) and normal level of consciousness at onset (OR 3.44; 95% CI: 1.93-6.12) were associated with greater post-stroke independence (mRs 0-2). Out of 395, 111 (28.1%) patients with no or minimal disability at 1 month (mRs 0-2), 32.4% showed worsening of disability (mRs 3-5) at 12 months.
Conclusion
At 1 year, 33% died and 36% were dependent. A large number (60%) of patients with minimal disability at 30 days worsened or died at 1 year.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2025. |
Keywords: | Stroke; outcome; modified Rankin scale; 1 year; long term; low- and middle-income countries; disability |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Feb 2025 16:28 |
Last Modified: | 21 Feb 2025 16:28 |
Status: | Published online |
Publisher: | SAGE Publications |
Refereed: | Yes |
Identification Number: | 10.1177/25166085251315219 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223659 |