Mancinelli, E., Miranda, A.S., Picton, H.M. et al. (1 more author) (2024) Structural and biocompatibility challenges for 3D printed microfluidic devices for IVF. In: 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 15-19 Jul 2024, Orlando, FL, USA. IEEE ISBN 979-8-3503-7150-5
Abstract
In Vitro Fertilization (IVF) is a widely used treatment for infertility, but success rates for UK women under 35 stand at approximately 32%. Culture conditions significantly affect in-vitro embryo development and treatment efficacy. Over 40 years, IVF procedures evolved, with microfluidic platforms emerging to enhance culture conditions. These platforms, designed to mimic a natural environment, show promise without negatively affecting development rates. However, potential impacts on embryo characteristics require further evaluation. The study introduces a microfluidic concept compatible with time-lapse microscopy. Two prototyping methods are compared, being soft lithography in PDMS and 3D printing in HTL resin. Results indicate successful prototype detection and loading efficiency, with the soft lithographic method showing a lower assembly yield. 3D printing facilitates rapid design, in particular for high aspect ratio microfluidic devices. However, viability assessments suggest additional steps are required to exclude material embryo toxicity of the resin.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
Keywords: | microfluidic, embryo culture, IVF, rapid prototyping |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Pollard Institute (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Feb 2025 11:04 |
Last Modified: | 13 Feb 2025 11:04 |
Published Version: | https://ieeexplore.ieee.org/document/10782247 |
Status: | Published |
Publisher: | IEEE |
Identification Number: | 10.1109/embc53108.2024.10782247 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223221 |