Rethinking phase 2 trials in amyotrophic lateral sclerosis

Benatar, M. orcid.org/0000-0003-4241-5135, McDermott, C. orcid.org/0000-0002-1269-9053, Turner, M.R. orcid.org/0000-0003-0267-3180 et al. (1 more author) (2024) Rethinking phase 2 trials in amyotrophic lateral sclerosis. Brain. awae396. ISSN 0006-8950

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Item Type: Article
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© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

Keywords: biomarkers; go/no-go decisions; multiplicity; outcome measures; result communication; trial design
Dates:
  • Published: 6 December 2024
  • Published (online): 6 December 2024
  • Accepted: 4 December 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User: Symplectic Sheffield
Date Deposited: 11 Feb 2025 13:05
Last Modified: 11 Feb 2025 13:05
Status: Published online
Publisher: Oxford University Press (OUP)
Refereed: Yes
Identification Number: 10.1093/brain/awae396
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Open Archives Initiative ID (OAI ID):

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