Griggs, S.D., Piticari, A.-S., Liver, S. et al. (4 more authors) (2025) Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds. Chemical Communications. ISSN 1359-7345
Abstract
An array of reactions of diazo substrates with many possible outcomes was executed, and the biological relevance of the resulting products assessed in the cell painting assay. Reactions that had yielded bioactive products were scaled-up, and the products structurally elucidated. By bypassing the need to characterise all reaction products, this phenotype-directed approach enabled efficient discovery of functionally-distinctive molecules based on novel, structurally-diverse scaffolds.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2025. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 3.0). |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/N025652/1 EPSRC (Engineering and Physical Sciences Research Council) EP/W002914/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2025 10:16 |
Last Modified: | 06 Feb 2025 10:16 |
Status: | Published online |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/d4cc06605g |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:222935 |