Britt, H.M. orcid.org/0000-0001-8510-0331 and Robinson, C.V. orcid.org/0000-0001-7829-5505 (2025) Traversing the drug discovery landscape using native mass spectrometry. Current Opinion in Structural Biology, 91. 102993. ISSN 0959-440X
Abstract
As health needs in our society evolve, the field of drug discovery must undergo constant innovation and improvement to identify novel targets and drug candidates. Owing to its ability to simultaneously capture biological interactions and provide in-depth molecular characterisation of the species involved, native mass spectrometry is starting to play an important role in this endeavour. Here, we discuss recent contributions that native mass spectrometry has made to drug discovery including deciphering protein-small molecule interactions, unravelling biochemical pathways, and integrating with complementary structural approaches.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Feb 2025 11:55 |
Last Modified: | 04 Feb 2025 11:55 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.sbi.2025.102993 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:222860 |