Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation

Abstract

We report the synthesis, characterization, and catalytic applications of N,N’-diaryl diazabutadiene (DAB) Ni(0) complexes stabilized by alkene ligands. These complexes are soluble and stable in several organic solvents, making them ideal candidates for in situ catalyst formation during high-throughput experimentation (HTE). We used HTE to evaluate these Ni(0) precatalysts in a variety of Suzuki and C−N coupling reactions, and they were found to have equal or better performance than the still-standard Ni(0) source, Ni(COD)₂.

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Item Type:	Article
Authors/Creators:	Thomas, G.T. https://orcid.org/0000-0002-1468-2714 Cruise, O.D. Peel-Smith, D. Fernández, N.P. Killeen, C. Leitch, D.C.
Copyright, Publisher and Additional Information:	© 2025 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords:	nickel precatalyst, homogenous catalysis, cross-coupling, high-throughput experimentation, organic synthesis
Dates:	Published: 25 February 2025 Published (online): 16 January 2025
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	03 Feb 2025 10:50
Last Modified:	24 Mar 2025 15:44
Status:	Published
Publisher:	Wiley
Identification Number:	10.1002/chem.202403960
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:222736

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Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation

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