Hydrogen–deuterium exchange mass spectrometry reveals mechanistic insights into RNA oligonucleotide-mediated inhibition of TDP-43 aggregation

Minshull, T.C., Byrd, E.J., Olejnik, M. et al. (1 more author) (2024) Hydrogen–deuterium exchange mass spectrometry reveals mechanistic insights into RNA oligonucleotide-mediated inhibition of TDP-43 aggregation. Journal of the American Chemical Society, 146 (49). pp. 33626-33639. ISSN 0002-7863

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Item Type: Article
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© 2024 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: DNA-Binding Proteins; RNA; Humans; Oligonucleotides; Hydrogen Deuterium Exchange-Mass Spectrometry; Protein Aggregates; Models, Molecular
Dates:
  • Published: 11 December 2024
  • Published (online): 29 November 2024
  • Accepted: 19 November 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering
Depositing User: Symplectic Sheffield
Date Deposited: 03 Feb 2025 11:41
Last Modified: 03 Feb 2025 11:41
Published Version: https://doi.org/10.1021/jacs.4c11229
Status: Published
Publisher: American Chemical Society (ACS)
Refereed: Yes
Identification Number: 10.1021/jacs.4c11229
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