Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Soukarieh, F. orcid.org/0000-0002-6730-2543, Mashabi, A. orcid.org/0000-0002-4807-2869, Richardson, W. et al. (17 more authors) (2024) Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. Journal of Medicinal Chemistry, 67 (2). pp. 1008-1023. ISSN 0022-2623

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Item Type: Article
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© 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. (https://creativecommons.org/licenses/by/4.0/)

Keywords: Humans; Pseudomonas Infections; Quorum Sensing; Biofilms; Quinolones; Anti-Bacterial Agents; Imidazoles; Pseudomonas aeruginosa; Bacterial Proteins; Virulence Factors
Dates:
  • Published: 25 January 2024
  • Published (online): 3 January 2024
  • Accepted: 12 December 2023
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Health Sciences School (Sheffield)
Funding Information:
Funder
Grant number
BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL
BB/R012415/1
Depositing User: Symplectic Sheffield
Date Deposited: 05 Feb 2025 14:38
Last Modified: 05 Feb 2025 14:38
Status: Published
Publisher: American Chemical Society (ACS)
Refereed: Yes
Identification Number: 10.1021/acs.jmedchem.3c00973
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