An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation

Edwards, S.M. orcid.org/0000-0001-5011-4688, Harding, A.L., Leedale, J.A. et al. (4 more authors) (2024) An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation. International Journal of Pharmaceutics, 666. 124827. ISSN 0378-5173

Abstract

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Item Type: Article
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© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ).

Keywords: Chemical toxicity; Drug delivery; In silico; Mathematical modelling; Oral mucosa; Permeation; Systems pharmacology; Toxicology; Mouth Mucosa; Humans; Computer Simulation; Permeability; Models, Biological; Extracellular Space; Tissue Engineering; Oral Mucosal Absorption
Dates:
  • Published: December 2024
  • Published (online): 14 October 2024
  • Accepted: 11 October 2024
  • Submitted: 28 April 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield)
Funding Information:
Funder
Grant number
NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT AND REDUCTION OF ANIMALS IN RESEARCH
NC/W001160/1
Depositing User: Symplectic Sheffield
Date Deposited: 24 Jan 2025 10:51
Last Modified: 24 Jan 2025 10:51
Status: Published
Publisher: Elsevier BV
Refereed: Yes
Identification Number: 10.1016/j.ijpharm.2024.124827
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