Da Luz, Jonathan, Dobah, Farhaan, Rossi-Ashton, James A. et al. (3 more authors) (2025) Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2-Isoxazolines via a Formal C(sp3)−H Functionalization. European Journal of Organic Chemistry. e202401369. ISSN 1099-0690
Abstract
The discovery of a dehydrogenative photoredox catalyzed formal C(sp3)−H intramolecular cyclization of indolyl-oximes to generate indolyl Δ2-isoxazolines is reported. In contrast to the current state-of-the-art, the reaction avoids the use of super stoichiometric chemical oxidants and high reaction temperatures and is proposed to operate via two sequential single electron oxidation events.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Publisher Copyright: © 2024 The Author(s). European Journal of Organic Chemistry published by Wiley-VCH GmbH. |
Keywords: | C−H functionalization,Indoles,Isoxazolines,Oximes,Photoredox catalysis |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Environment and Geography (York) |
Depositing User: | Pure (York) |
Date Deposited: | 21 Jan 2025 18:18 |
Last Modified: | 11 Feb 2025 00:13 |
Published Version: | https://doi.org/10.1002/ejoc.202401369 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/ejoc.202401369 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:222139 |
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Description: Eur J Org Chem - 2024 - Da Luz - Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl 2‐Isoxazolines via a Formal C
Licence: CC-BY 2.5