Design and in vitro anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

Poole, S., Aning, O.A., McKee, V. et al. (12 more authors) (2025) Design and in vitro anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease. Nucleic Acids Research, 53 (1). gkae1250. ISSN 0305-1048

Abstract

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Item Type: Article
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Copyright, Publisher and Additional Information:

© The Author(s) 2025. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Click Chemistry; Humans; Copper; Antineoplastic Agents; DNA; Cell Line, Tumor; DNA Cleavage; DNA Repair; Deoxyribonucleases; Phenanthrolines; Ligands
Dates:
  • Published: 13 January 2025
  • Published (online): 7 January 2025
  • Accepted: 10 December 2024
  • Submitted: 24 May 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering
Funding Information:
Funder
Grant number
UK RESEARCH AND INNOVATION
MR/W00738X/1
Depositing User: Symplectic Sheffield
Date Deposited: 17 Jan 2025 14:39
Last Modified: 17 Jan 2025 14:39
Status: Published
Publisher: Oxford University Press (OUP)
Refereed: Yes
Identification Number: 10.1093/nar/gkae1250
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