In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells

O’Connor, A.P., Amariutei, A.E., Zanella, A. et al. (9 more authors) (2024) In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. JCI Insight, 9 (23). e182138. ISSN 2379-3708

Abstract

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Item Type: Article
Authors/Creators:
Copyright, Publisher and Additional Information:

© 2024, O’Connor et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Keywords: Aging; Gene therapy; Genetic diseases; Mouse models; Neuroscience; Animals; Hair Cells, Auditory, Inner; Dependovirus; Mice; Myosin VIIa; Hearing; Cochlea; Male; Spiral Ganglion; Genetic Therapy; Female; Genetic Vectors; Cholinergic Neurons
Dates:
  • Published: 6 December 2024
  • Published (online): 6 December 2024
  • Accepted: 16 October 2024
  • Submitted: 16 April 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Funding Information:
Funder
Grant number
BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL
BB/T004991/1
WELLCOME TRUST (THE)
224326/Z/21/Z
BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL
BB/X000567/1
Depositing User: Symplectic Sheffield
Date Deposited: 09 Jan 2025 10:56
Last Modified: 09 Jan 2025 10:56
Status: Published
Publisher: American Society for Clinical Investigation
Refereed: Yes
Identification Number: 10.1172/jci.insight.182138
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Open Archives Initiative ID (OAI ID):

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