Delvenne, J.-F. orcid.org/0000-0002-1990-9738 and Malloy, E. (2025) Functional implications of age-related atrophy of the corpus callosum. Neuroscience & Biobehavioral Reviews, 169. 105982. ISSN 0149-7634
Abstract
The corpus callosum plays a critical role in inter-hemispheric communication by coordinating the transfer of sensory, motor, cognitive, and emotional information between the two hemispheres. However, as part of the normal aging process, the corpus callosum undergoes significant structural changes, including reductions in both its size and microstructural integrity. These age-related alterations can profoundly impact the brain's ability to coordinate functions across hemispheres, leading to a decline in various aspects of sensory processing, motor coordination, cognitive functioning, and emotional regulation. This review aims to synthesize current research on age-related changes in the corpus callosum, examining the regional differences in atrophy, its underlying causes, and its functional implications. By exploring these aspects, we seek to emphasize the clinical significance of corpus callosum degeneration and its impact on the quality of life in older adults, as well as the potential for early detection and targeted interventions to preserve brain health during aging. Finally, the review calls for further research into the mechanisms underlying corpus callosum atrophy and its broader implications for aging.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Corpus callosum, Brain atrophy, White matter degeneration, Functional decline |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Jan 2025 14:27 |
Last Modified: | 02 Jan 2025 14:27 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.neubiorev.2024.105982 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:221072 |