Patel, Priya, Robinson, Paula D, Fisher, Brian T et al. (15 more authors) (2024) Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients:2024 update. EClinicalMedicine. 102604. ISSN 2589-5370
Abstract
Our objective was to update a clinical practice guideline for the prevention and treatment of Clostridioides difficile infection (CDI) in pediatric patients with cancer and hematopoietic cell transplantation recipients. We reconvened an international multi-disciplinary panel. A systematic review of randomized controlled trials (RCTs) for the prevention or treatment of CDI in any population was updated and identified 31 new RCTs. Strong recommendations were made to use either oral metronidazole or oral vancomycin for non-severe CDI treatment, and to use either oral vancomycin or oral fidaxomicin for severe CDI. A strong recommendation that fecal microbiota transplantation should not be routinely used to treat CDI was also made. The panel made two new good practice statements to follow infection control practices including isolation in patients experiencing CDI, and to minimize systemic antibacterial administration where feasible, especially in patients who have experienced CDI.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Social Sciences (York) > Centre for Reviews and Dissemination (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 19 Dec 2024 00:20 |
Last Modified: | 23 Jan 2025 00:37 |
Published Version: | https://doi.org/10.1016/j.eclinm.2024.102604 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.eclinm.2024.102604 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:221003 |
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Filename: 1-s2.0-S2589537024001834-main.pdf
Description: Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update
Licence: CC-BY-NC-ND 2.5