Conway, M. orcid.org/0009-0005-4448-8401, Oncul, M., Allen, K. et al. (2 more authors) (2024) Perceptual constancy for an odor is acquired through changes in primary sensory neurons. Science Advances, 10 (50). eado9205. ISSN 2375-2548
Abstract
The ability to consistently recognize an object despite variable sensory input is termed perceptual constancy. This ability is not innate; rather, it develops with experience early in life. We show that, when mice are naïve to an odor object, perceptual constancy is absent across increasing concentrations. The perceptual change coincides with a rapid reduction in activity from a single olfactory receptor channel that is most sensitive to the odor. This drop in activity is not a property of circuit interactions within the olfactory bulb; instead, it is due to a sensitivity mismatch of olfactory receptor neurons within the nose. We show that, after forming an association of this odor with food, the sensitivity of the receptor channel is matched to the odor object, preventing transmission failure and promoting perceptual stability. These data show that plasticity of the primary sensory organ enables learning of perceptual constancy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Dec 2024 11:15 |
Last Modified: | 18 Dec 2024 11:15 |
Status: | Published |
Publisher: | American Association for the Advancement of Science (AAAS) |
Identification Number: | 10.1126/sciadv.ado9205 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:220944 |