Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism

Lombardi, G. orcid.org/0000-0002-8365-985X, Jørgensen, N.R. orcid.org/0000-0001-9624-5210, Harvey, N.C. orcid.org/0000-0002-8194-2512 et al. (14 more authors) (2025) Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism. Clinical Chemistry and Laboratory Medicine (CCLM), 63 (4). pp. 704-711. ISSN 1434-6621

Abstract

The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline proposes the nomenclature Bone Status Indices (BSI) as the comprehensive classification rather than bone turnover markers, bone markers, metabolic markers of bone turnover or metabolic markers of bone turnover, that are currently in use for the implicated molecules. On behalf of the IFCC Committee on Bone Metabolism and the Joint IOF Working Group and IFCC Committee on Bone Metabolism, the authors propose standardized nomenclature, abbreviations and measurement units for the bone status indices.

Metadata

Item Type:	Article
Authors/Creators:	Lombardi, G. https://orcid.org/0000-0002-8365-985X Jørgensen, N.R. https://orcid.org/0000-0001-9624-5210 Harvey, N.C. https://orcid.org/0000-0002-8194-2512 McCloskey, E.V. https://orcid.org/0000-0003-0177-8140 Åkesson, K.E. https://orcid.org/0000-0003-3024-2804 Eastell, R. https://orcid.org/0000-0002-0323-3366 Garnero, P. https://orcid.org/0000-0003-0939-5099 Kanis, J.A. https://orcid.org/0000-0002-3129-4326 Khashayar, P. https://orcid.org/0000-0001-7525-8418 Lane, N.E. McClung, M.R. https://orcid.org/0000-0002-7827-0778 Silverman, S. https://orcid.org/0000-0002-5313-1018 Makris, K. https://orcid.org/0000-0002-7896-9028 Bhattoa, H.P. https://orcid.org/0000-0002-4909-0065 Vasikaran, S.D. https://orcid.org/0000-0002-0831-3031 Pikner, R. https://orcid.org/0000-0002-0633-8876 Cavalier, E. https://orcid.org/0000-0003-0947-2226
Copyright, Publisher and Additional Information:	© 2024 The Authors. Except as otherwise noted, this author-accepted version of a journal article published in Clinical Chemistry and Laboratory Medicine is made available via the University of Sheffield Research Publications and Copyright Policy under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Keywords:	bone status indices; nomenclature; standardization
Dates:	Published: 21 February 2025 Published (online): 25 November 2024 Accepted: 5 November 2024 Submitted: 2 October 2024
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User:	Symplectic Sheffield
Date Deposited:	13 Dec 2024 17:24
Last Modified:	19 Mar 2025 14:00
Status:	Published
Publisher:	Walter de Gruyter GmbH
Refereed:	Yes
Identification Number:	10.1515/cclm-2024-1148
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:220829

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Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism

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