Chapple, C.R. orcid.org/0000-0002-2960-9931, Bullock, A.J. orcid.org/0000-0003-0579-3997 and MacNeil, S. orcid.org/0000-0002-2368-7955 (2024) Where are we in 2024 in the development of materials for surgical treatment of pelvic organ prolapse and stress urinary incontinence? Current Opinion in Urology, 34 (6). pp. 433-437. ISSN 0963-0643
Abstract
Purpose of review
There is a long history of implantation of absorbable and nonabsorbable materials to treat stress urinary incontinence (SUI) and pelvic organ prolapse (POP). The focus of this review is to review the development of new materials for use in the surgical management of both pelvic conditions following an unacceptable level of severe complications in the use of polypropylene mesh (PPM). We discuss current concepts relating to the development of new materials with particular reference to our experience with polyurethane mesh.
Recent findings
Our review highlights the strategies that manufacturers and researchers are employing to improve PPM using collagen gels and stem cells, or to find alternatives. We conclude that current preclinical safety testing is inadequate, and the field requires better in vivo testing. Specifically, we highlight novel techniques demonstrating the degradation of polypropylene potentially elucidating the link between PPM degradation and induction of inflammation leading to adverse side effects.
Summary
This field badly needs innovation in developing new materials and in testing these to ensure materials will benefit patients. A collaboration between materials scientists and clinicians is needed to facilitate the translation of basic research and preclinical testing into patient benefit for the treatment of SUI and POP.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Wolters Kluwer Health |
Keywords: | Humans; Urinary Incontinence, Stress; Pelvic Organ Prolapse; Surgical Mesh; Polypropylenes; Animals; Female; Polyurethanes; Materials Testing; Urologic Surgical Procedures |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Dec 2024 10:29 |
Last Modified: | 13 Dec 2024 10:29 |
Status: | Published |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Refereed: | Yes |
Identification Number: | 10.1097/mou.0000000000001217 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:220786 |