Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Schwalm, Martin P, Dopfer, Johannes, Kumar, Adarsh et al. (23 more authors) (2024) Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets. Nature Communications. 10204. ISSN 2041-1723

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Schwalm, Martin P
  • Dopfer, Johannes
  • Kumar, Adarsh
  • Greco, Francesco A
  • Bauer, Nicolas
  • Löhr, Frank
  • Heering, Jan
  • Cano-Franco, Sara
  • Lechner, Severin
  • Hanke, Thomas
  • Jaser, Ivana
  • Morasch, Viktoria
  • Lenz, Christopher
  • Fearon, Daren
  • Marples, Peter G
  • Tomlinson, Charles W E ORCID logo https://orcid.org/0000-0002-1845-6028
  • Brunello, Lorene
  • Saxena, Krishna
  • Adams, Nathan B P
  • von Delft, Frank
  • Müller, Susanne
  • Stolz, Alexandra
  • Proschak, Ewgenij
  • Kuster, Bernhard
  • Knapp, Stefan
  • Rogov, Vladimir V
Copyright, Publisher and Additional Information:

© 2024. The Author(s).

Keywords: Microtubule-Associated Proteins/metabolism,Ligands,Humans,Apoptosis Regulatory Proteins/metabolism,Binding Sites,Molecular Docking Simulation,Adaptor Proteins, Signal Transducing/metabolism,Autophagosomes/metabolism,Protein Binding,Autophagy,Crystallography, X-Ray
Dates:
  • Published: 25 November 2024
  • Accepted: 8 November 2024
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Biology (York)
Depositing User: Pure (York)
Date Deposited: 28 Nov 2024 11:30
Last Modified: 02 Dec 2024 01:18
Published Version: https://doi.org/10.1038/s41467-024-54409-5
Status: Published
Refereed: Yes
Identification Number: 10.1038/s41467-024-54409-5
Open Archives Initiative ID (OAI ID):

Download

Filename: s41467-024-54409-5.pdf

Description: Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.

Licence: CC-BY 2.5

Export

Statistics