Dye, L. orcid.org/0000-0002-2331-4227, Boyle, N.B. orcid.org/0000-0002-0604-4712, Champ, C. et al. (1 more author) (2017) The relationship between obesity and cognitive health and decline. In: Gallagher, A., (ed.) Proceedings of the Nutrition Society. The Joint Winter Meeting between the Nutrition Society and the Royal Society of Medicine, 06-07 Dec 2016, London, United Kingdom. Cambridge University Press (CUP) , pp. 443-454.
Abstract
The relationship between obesity and cognitive impairment is important given the globally ageing population in whom cognitive decline and neurodegenerative disorders will carry grave individual, societal and financial burdens. This review examines the evidence for the link between obesity and cognitive function in terms of both the immediate effects on cognitive performance, and effects on the trajectory of cognitive ageing and likelihood of dementia. In mid-life, there is a strong association between obesity and impaired cognitive function. Anthropometric measures of obesity are also associated with reduced neural integrity (e.g. grey and white matter atrophy). Increasing age coupled with the negative metabolic consequences of obesity (e.g. type 2 diabetes mellitus) are likely to significantly contribute to cognitive decline and incidence of dementia. Stress is identified as a potential risk factor promoting abdominal obesity and contributing to impaired cognitive function. However, the potentially protective effects of obesity against cognitive decline in older age require further examination. Finally, surgical and whole diet interventions, which address obesity may improve cognitive capacity and confer some protection against later cognitive decline. In conclusion, obesity and its comorbidities are associated with impaired cognitive performance, accelerated cognitive decline and neurodegenerative pathologies such as dementia in later life. Interventions targeting mid-life obesity may prove beneficial in reducing the cognitive risks associated with obesity.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © The Authors 2017 |
Keywords: | AD Alzheimer's disease; IGT impaired glucose tolerance; MDP Mediterranean dietary pattern; T2DM type 2 diabetes mellitus; WHR waist-to-hip ratio; Cognitive decline; Cognitive performance; Dementia; Obesity; Aged; Aged, 80 and over; Cognition; Cognitive Aging; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Obesity; Risk Factors |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Nov 2024 09:25 |
Last Modified: | 28 Nov 2024 10:22 |
Status: | Published |
Publisher: | Cambridge University Press (CUP) |
Refereed: | Yes |
Identification Number: | 10.1017/s0029665117002014 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:220182 |