Sun, S., Tao, J., Sedghizadeh, P.P. et al. (13 more authors) (2021) Bisphosphonates for delivering drugs to bone. British Journal of Pharmacology, 178 (9). pp. 2008-2025. ISSN 0007-1188
Abstract
Advances in the design of potential bone-selective drugs for the treatment of various bone-related diseases are creating exciting new directions for multiple unmet medical needs. For bone-related cancers, off-target/non-bone toxicities with current drugs represent a significant barrier to the quality of life of affected patients. For bone infections and osteomyelitis, bacterial biofilms on infected bones limit the efficacy of antibiotics because it is hard to access the bacteria with current approaches. Promising new experimental approaches to therapy, based on bone-targeting of drugs, have been used in animal models of these conditions and demonstrate improved efficacy and safety. The success of these drug-design strategies bodes well for the development of therapies with improved efficacy for the treatment of diseases affecting the skeleton.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The British Pharmacological Society |
Keywords: | antibiotic; biofilm; bisphosphonate; bone resorption; bone targeting; conjugate; multiple myeloma; osteomyelitis; Animals; Bacteria; Biofilms; Diphosphonates; Humans; Pharmaceutical Preparations; Quality of Life |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Nov 2024 09:58 |
Last Modified: | 25 Nov 2024 11:46 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/bph.15251 |
Related URLs: | |
Sustainable Development Goals: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:220025 |