Huang, Y., Cromarty, R., Jia, L. et al. (4 more authors) (2024) Attention network dysfunctions in Lewy body dementia and Alzheimer’s disease. Journal of Clinical Medicine, 13 (22). 6691. ISSN 2077-0383
Abstract
Background: Attention deficits are notable in Lewy body dementia (LBD) and in Alzheimer’s disease (AD). In this study, we combined functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG) to detect neural correlates of attention dysfunctions in LBD and AD. Methods: We recruited 33 patients with LBD, 15 patients with AD and 19 elderly healthy controls. The participants performed the modified Attention Network Task (ANT) to investigate the attention dysfunctions. Results: We found that LBD had alerting attention deficits and AD showed apparent orienting attention dysfunctions, while LBD and AD maintained relatively normal executive/conflict attention. Based on source-level EEG analyses, LBD had frontal-central deficits for alerting attention while AD showed inferior frontal and precentral impairments for orienting attention. In addition, the insular and inferior frontal areas were hyper-activated in LBD and AD for executive/conflict attention. Apart from these areas, LBD showed activity in the complementary temporal-central-occipital network for the modified ANT task. Furthermore, the oscillational sources for the ANT effects indicated that the alpha and theta bands were partly impaired in dementia patients. Conclusions: In summary, using source-localised EEG, we found that attention dysfunctions in LBD and AD engaged different neural networks.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | attention dysfunction; source-level electroencephalograph; functional magnetic resonance imaging; Lewy body dementia; Alzheimer’s disease; ANT |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number Alzheimer’s Research UK ARUK-SRF2017B-1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Nov 2024 15:45 |
Last Modified: | 20 Nov 2024 15:45 |
Status: | Published |
Publisher: | MDPI AG |
Refereed: | Yes |
Identification Number: | 10.3390/jcm13226691 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:219915 |