Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Wang, Rongling, Gomez Salazar, Mario, Pruñonosa Cervera, Iris et al. (19 more authors) (2024) Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality. Nature Communications. 7483. ISSN 2041-1723

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Wang, Rongling
  • Gomez Salazar, Mario
  • Pruñonosa Cervera, Iris
  • Coutts, Amanda
  • French, Karen
  • Pinto, Marlene Magalhaes
  • Gohlke, Sabrina
  • García-Martín, Ruben
  • Blüher, Matthias
  • Schofield, Christopher J
  • Kourtzelis, Ioannis ORCID logo https://orcid.org/0000-0003-3006-8885
  • Stimson, Roland H
  • Bénézech, Cécile
  • Christian, Mark
  • Schulz, Tim J
  • Gudmundsson, Elias F
  • Jennings, Lori L
  • Gudnason, Vilmundur G
  • Chavakis, Triantafyllos
  • Morton, Nicholas M
  • Emilsson, Valur
  • Michailidou, Zoi
Copyright, Publisher and Additional Information:

© 2024. The Author(s).

Keywords: Animals,Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism,Humans,Energy Metabolism,Mice,Adipose Tissue, Brown/metabolism,Thermogenesis/genetics,Uncoupling Protein 1/metabolism,Male,Mice, Knockout,Female,Basic Helix-Loop-Helix Transcription Factors/metabolism,Adipocytes/metabolism,Oxygen/metabolism,Mice, Inbred C57BL,Adipocytes, Brown/metabolism,Adult,Promoter Regions, Genetic,Middle Aged
Dates:
  • Published: 29 August 2024
  • Accepted: 14 August 2024
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Hull York Medical School (York)
Depositing User: Pure (York)
Date Deposited: 15 Nov 2024 10:30
Last Modified: 23 Jan 2025 00:36
Published Version: https://doi.org/10.1038/s41467-024-51718-7
Status: Published
Refereed: Yes
Identification Number: 10.1038/s41467-024-51718-7
Open Archives Initiative ID (OAI ID):

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Filename: s41467-024-51718-7.pdf

Description: Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Licence: CC-BY 2.5

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