A novel therapeutic pathway to the human cochlear nerve

Abstract

Traditional approaches to the human cochlear nerve have been impeded by its bony encasement deep inside the skull base. We present an innovative, minimally invasive, therapeutic pathway for direct access to the nerve to deliver novel regenerative therapies. Neuroanatomical studies on 10 cadaveric human temporal bones were undertaken to identify a potentially safe therapeutic pathway to the cochlear nerve. Simulations based on three-dimensional delineation of anatomical structures obtained from synchrotron phase-contrast imaging were analyzed. This enabled the identification of an approach to the nerve in the fundus of the internal auditory meatus by trephining the medial modiolar wall of the cochlea via the round window for a median depth of 1.48 mm (range 1.21-1.91 mm). The anatomical access was validated on 9 additional human temporal bones using radio-opaque markers and contrast injection with micro-computed tomography surveillance. We thus created an effective conduit for the delivery of therapeutic agents to the cochlear nerve.

Metadata

Item Type:	Article
Authors/Creators:	Li, H. Agrawal, S. Zhu, N. Cacciabue, D.I. Rivolta, M.N. Hartley, D.E.H. Jiang, D. Ladak, H.M. O’Donoghue, G.M. Rask‑Andersen, H. https://orcid.org/0009-0006-5736-0981
Copyright, Publisher and Additional Information:	© 2024 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Keywords:	Cochlear nerve; Deafness; Gene Therapy; Human; Micro-CT; Stem cell therapy; Synchrotron Imaging; Humans; Cochlear Nerve; Temporal Bone; X-Ray Microtomography; Cochlea; Imaging, Three-Dimensional; Cadaver
Dates:	Published: 5 November 2024 Published (online): 5 November 2024 Accepted: 27 September 2024
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	12 Nov 2024 16:03
Last Modified:	12 Nov 2024 16:03
Published Version:	http://dx.doi.org/10.1038/s41598-024-74661-5
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	10.1038/s41598-024-74661-5
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:219468

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A novel therapeutic pathway to the human cochlear nerve

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