Cardno, A.G. orcid.org/0000-0002-6136-5965, Allardyce, J. orcid.org/0000-0003-4094-552X, Bakker, S.C. et al. (15 more authors) (2025) Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples. The British Journal of Psychiatry, 226 (1). pp. 16-23. ISSN 0007-1250
Abstract
Background Positive, negative and disorganised psychotic symptom dimensions are associated with clinical and developmental variables, but differing definitions complicate interpretation. Additionally, some variables have had little investigation.
Aims To investigate associations of psychotic symptom dimensions with clinical and developmental variables, and familial aggregation of symptom dimensions, in multiple samples employing the same definitions.
Method We investigated associations between lifetime symptom dimensions and clinical and developmental variables in two twin and two general psychosis samples. Dimension symptom scores and most other variables were from the Operational Criteria Checklist. We used logistic regression in generalised linear mixed models for combined sample analysis (n = 875 probands). We also investigated correlations of dimensions within monozygotic (MZ) twin pairs concordant for psychosis (n = 96 pairs).
Results Higher symptom scores on all three dimensions were associated with poor premorbid social adjustment, never marrying/cohabiting and earlier age at onset, and with a chronic course, most strongly for the negative dimension. The positive dimension was also associated with Black and minority ethnicity and lifetime cannabis use; the negative dimension with male gender; and the disorganised dimension with gradual onset, lower premorbid IQ and substantial within twin-pair correlation. In secondary analysis, disorganised symptoms in MZ twin probands were associated with lower premorbid IQ in their co-twins.
Conclusions These results confirm associations that dimensions share in common and strengthen the evidence for distinct associations of co-occurring positive symptoms with ethnic minority status, negative symptoms with male gender and disorganised symptoms with substantial familial influences, which may overlap with influences on premorbid IQ.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s), 2024. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Psychosis, symptoms, twins, familial, intelligence |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/J004391/1 Wellcome Trust NOT GIVEN |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Nov 2024 12:06 |
Last Modified: | 06 Mar 2025 14:09 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1192/bjp.2024.129 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:219132 |