Smith, A.B. orcid.org/0000-0002-5750-7772, Retzler, J. orcid.org/0000-0002-0008-3104 and Taylor, M.J. (2020) Standard Gamble to Derive Utility Health States for Limbal Stem Cell Deficiency. ClinicoEconomics and Outcomes Research, 12. pp. 535-546. ISSN 1178-6981
Abstract
Purpose: To generate UK health-related quality-of-life (HRQoL) data for adult patients with moderate-to-severe limbal stem cell deficiency (LSCD), unilateral or bilateral, due to physical or chemical ocular burns to help inform economic evaluations of treatments. Patients and Methods: EQ-5D-3L with vision bolt-on scores was prospectively measured for one of five clinical scenarios of LSCD described in vignettes in a demographically representative population of 520 UK adults. These were converted to health state utilities using three different UK value sets. A standard gamble (SG) was then undertaken using 12 SG scenarios to examine the component drivers of health utility for the treatment of LSCD. Results: For the EQ-5D-3L scenarios, the mean disutility for LSCD with poor visual acuity, pain and disfigurement in both eyes compared to one eye was − 0.084 (range=− 0.156 to − 0.045 across the value sets). The mean disutility of bilateral LSCD with pain, disfigurement, and poor visual acuity compared to unilateral LSCD with only poor visual acuity in one eye was − 0.104 (range=− 0.151 to − 0.078). Similarly, where one eye was affected, pain and disfigurement in combination were associated with a greater mean disutility than improvements in visual acuity alone: − 0.011 (range=− 0.04 to 0.005). Mean SG utilities were within a narrow range (0.682– 0.765). Where one eye was affected, the main driver was disfigurement: mean utility was 0.731 (0.709– 0.753) compared to 0.682 (0.659– 0.704) when disfigurement was removed compared to vision restored to normal. For bilateral LSCD, mean utilities were 0.693 (0.672– 0.715) for normal vision and 0.75 (0.73– 0.771) when disfigurement and pain were removed. Conclusion: Improvements in pain and disfigurement appeared to be the main factors driving differences in health utilities associated with symptom profiles in LSCD, with improvements in visual acuity having lesser impact.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Smith et al. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY-NC 3.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | standard gamble, utility states, limbal stem cell deficiency, LSCD, ocular burns, holoclar |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Oct 2024 15:15 |
Last Modified: | 24 Oct 2024 15:15 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.2147/ceor.s251918 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:218800 |
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