Quality by design for mRNA platform purification based on continuous oligo-dT chromatography

Qu, J. orcid.org/0009-0002-5293-0413, Nair, A. orcid.org/0000-0002-2592-116X, Muir, G.W. et al. (7 more authors) (2024) Quality by design for mRNA platform purification based on continuous oligo-dT chromatography. Molecular Therapy - Nucleic Acids, 35 (4). 102333. ISSN 2162-2531

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Item Type: Article
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© 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: MT: Delivery Strategies; oligo-dT affinity chromatography; multi-column continuous chromatography process; quality by design; mRNA vaccines; mRNA therapeutics; Continuous manufacturing
Dates:
  • Published: 10 December 2024
  • Published (online): 11 September 2024
  • Accepted: 5 September 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering
The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield)
Funding Information:
Funder
Grant number
WELLCOME LEAP INC
UNSPECIFIED
Depositing User: Symplectic Sheffield
Date Deposited: 02 Oct 2024 09:48
Last Modified: 02 Oct 2024 11:21
Status: Published
Publisher: Elsevier BV
Refereed: Yes
Identification Number: 10.1016/j.omtn.2024.102333
Open Archives Initiative ID (OAI ID):

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