Beech, D.J. orcid.org/0000-0002-7683-9422, Fagnen, C. and Kalli, A.C. (2024) Biological sensing of fluid flow - lessons from PIEZO1. Biophysical Reviews, 16 (6). pp. 871-873. ISSN 1867-2450
Abstract
The flow sensing endothelial cell lining of blood and lymphatic vessels is essential in vertebrates. While the mechanisms are still mysterious in many regards, several critical components became apparent through molecular biology studies. In this article, we focus on PIEZO1, which forms unusual force-sensing ion channels capable of rapid transduction of force into biological effect. We describe current knowledge and emerging challenges. We suggest the idea of using computation to construct the flow sensing mechanism of endothelium to advance understanding, develop testable hypotheses and potentially design novel therapeutic strategies and synthetic flow sensing devices.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12551-024-01246-x |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation RG/17/11/33042 British Heart Foundation PG/21/10595 British Heart Foundation PG/21/10515 |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Oct 2024 10:58 |
Last Modified: | 12 Feb 2025 11:11 |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s12551-024-01246-x |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217836 |
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Filename: Beech et al Biophys Rev 2Oct24 author accepted.pdf
