Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children

Abstract

What is Known Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction.

What is New In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes.

BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying.

Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use.

In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating.

Metadata

Item Type:	Article
Authors/Creators:	Homan, M. https://orcid.org/0000-0001-5764-5430 Thomson, M. Bontems, P. Saccomani, M.D. Dias, J.A. Faraci, S. Furlano, R. Hojsak, I. Ledder, O. Slae, M. Narula, P. Nita, A.F. Norsa, L. Oliva, S. Papadopoulou, A. Romano, C. Rybak, A. Spyropoulou, V. Tambucci, R. Tzivinikos, C. van Wijk, M. Borrelli, O.
Copyright, Publisher and Additional Information:	© 2024 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made: https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords:	constipation; oesophagus; weight loss
Dates:	Published: December 2024 Published (online): 24 September 2024 Accepted: 5 September 2024
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	30 Sep 2024 09:41
Last Modified:	25 Feb 2025 15:41
Published Version:	http://dx.doi.org/10.1002/jpn3.12376
Status:	Published
Publisher:	Wiley
Refereed:	Yes
Identification Number:	10.1002/jpn3.12376
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:217716

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Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children

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