Pascual, Stéphanie, Noble, Brooklyn, Ahmad-Saeed, Nusreen et al. (69 more authors) (2024) Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections:a real-world evidence study. Journal of bone and joint infection. pp. 87-97. ISSN 2206-3552
Abstract
Introduction: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods: A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results: A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4 % and 85 % respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on Staphylococcus aureus, Streptococcus species, Enterococcus faecalis, Kingella kingae, Neisseria gonorrhoeae, and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1 h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies. Conclusion: The study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © Author(s) 2024 |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 25 Sep 2024 11:30 |
Last Modified: | 16 Oct 2024 20:09 |
Published Version: | https://doi.org/10.5194/jbji-9-87-2024 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.5194/jbji-9-87-2024 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217622 |
Download
Filename: jbji-9-87-2024.pdf
Description: Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study
Licence: CC-BY 2.5