Ismail, V.S., Britt, H.M., Mosely, J.A. et al. (1 more author) (2021) Peptide lipidation in lysophospholipid micelles and lysophospholipid-enriched membranes. Faraday Discussions, 232. pp. 282-294. ISSN 1359-6640
Abstract
Acyl transfer from lipids to membrane-associated peptides is a well-documented process, leading to the generation of a lipidated peptide and a lysolipid. In this article, we demonstrate that acyl transfer from lysophosphatidylcholines (lysoPCs) to the peptide melittin also occurs, both in micelles of pure lysolipid and in lipid/lysolipid mixtures. In the case of bilayers containing lysolipids, acyl transfer from the lysolipid is marginally favoured over transfer from the lipid. In pure bilayers of saturated lipids, the introduction of even small amounts of lysolipid appears to significantly increase the reactivity towards lipidation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 3.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Sep 2024 10:59 |
Last Modified: | 24 Sep 2024 10:59 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/d1fd00030f |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217539 |