Montgomery, James R.D., Gates, Emma L., Smith, Marshall J. et al. (8 more authors) (2024) Ultraselective, Ultrahigh Resolution 1D TOCSY. Chemistry-Methods. e202400013. ISSN 2628-9725
Abstract
Solution state 1H NMR spectroscopy provides valuable insights into molecular structure and conformation. However, when the spectrum exhibits severe signal overlap, it hampers the extraction of key structural information. Here, an ultraselective, ultrahigh resolution TOCSY method is introduced that greatly reduces spectral complexity, allowing the extraction of previously inaccessible spectral information. It combines the recently developed GEMSTONE excitation with homonuclear decoupling to provide highly simplified through-bond correlation 1D 1H NMR spectra, showing all signals within the selected spin system as singlets. The new method can greatly facilitate the analysis of mixtures, as shown here for a mixture of Cinchona alkaloids (popular catalysts in asymmetric synthesis) and a mixture of glucocorticoids (used for treating conditions such as asthma).
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | Publisher Copyright: © 2024 The Author(s). Chemistry - Methods published by Chemistry Europe and Wiley-VCH GmbH. |
Keywords: | GEMSTONE,Mixture Analysis,NMR Spectroscopy,Pure Shift,TOCSY |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Psychology (York) The University of York > Faculty of Sciences (York) > Psychology (York) > York Neuroimaging Centre |
Depositing User: | Pure (York) |
Date Deposited: | 19 Sep 2024 16:10 |
Last Modified: | 18 Dec 2024 00:26 |
Published Version: | https://doi.org/10.1002/cmtd.202400013 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/cmtd.202400013 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217419 |
Download
Filename: Chemistry_Methods_-_2024_-_Montgomery_-_Ultraselective_Ultrahigh_Resolution_1D_TOCSY.pdf
Description: Chemistry Methods - 2024 - Montgomery - Ultraselective Ultrahigh Resolution 1D TOCSY
Licence: CC-BY 2.5