Rathnam, S.R., Reddy, O.S., Aravind, S. et al. (2 more authors) (2024) Development of pH-Sensitive Microbeads Incorporated with Amine-functionalized Magnetic Nanoparticles for Enhanced Antibacterial Activity. ChemistrySelect, 9 (37). e202400340. ISSN 2365-6549
Abstract
Antibiotic-resistant bacteria have rapidly emerged in recent years as a result of irrational use of antibiotics. The development of drug carriers that can enhance antibacterial activity of antibiotics can potentially overcome antibiotic resistance and hence has practical significance. This study addresses this need by integrating amine-functionalized magnetic nanoparticles (AMNPs) into hydrogel microbeads composed of sodium alginate (SA) and xanthan gum (XG) for delivery of levofloxacin (LVX). Characterization of the microbeads confirmed successful AMNP–polymer interactions and demonstrated a porous structure inside the microbeads. The microbeads demonstrated pH-sensitive drug release behavior, enabling prolonged drug release. The drug encapsulation efficiency in the hydrogel microbeads was higher after AMNP incorporation, indicating the potential roles played by the porous network and by AMNP-LVX interactions during drug loading. The microbeads adhered to first-order, Higuchi, and Korsmeyer-Peppas kinetic models, suggesting that a combination of diffusion and polymer relaxation mechanisms is involved in drug release. Along with the fact that the AMNP-incorporated microbeads exhibited enhanced antibacterial activity against various bacterial strains, our microbeads warrant further development and optimization as drug carriers for antibacterial applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is the peer reviewed version of the following article: S. R. Rathnam, O. S. Reddy, S. Aravind, W.-F. Lai, S. B. Patwari, Development of pH-Sensitive Microbeads Incorporated with Amine-Functionalized Magnetic Nanoparticles for Enhanced Antibacterial Activity. ChemistrySelect 2024, 9, e202400340. https://doi.org/10.1002/slct.202400340, which has been published in final form at https://doi.org/10.1002/slct.202400340. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
Keywords: | Amine-functionalized magnetic nanoparticles, Antibacterial activity, Levofloxacin, Sodium alginate, Xanthan gum |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Sep 2024 14:25 |
Last Modified: | 30 Sep 2024 08:24 |
Published Version: | https://chemistry-europe.onlinelibrary.wiley.com/d... |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/slct.202400340 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217357 |
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Filename: WRRO_Development of pH.pdf
