Treatment and rehabilitation of Long COVID:A scope of the literature. Update April 2024

We identified 15 randomised controlled trials published between December 2023 and March 2024 that were focused on Long COVID treatment or rehabilitation. Across our eight reports produced to date, we have identified and assessed 121 trials published between January 2022 and March 2024. • Seven of the 15 trials focused on treating generalised or multiple symptoms of Long COVID/Post COVID condition. Three trials evaluated treatments for fatigue, one of which also focused on individuals with other neuropsychiatric sequalae. Two trials had a focus on respiratory or cardiovascular function or physical fitness. Two other trials focused on persistent problems with the sense of smell or taste (olfactory/gustatory dysfunction). One trial focused on people with decreased functioning and participation in daily life following COVID-19. • Two trials were rated positively for 12 out of the 13 quality criteria that we assessed. Two trials met ten criteria and 11 gained a positive rating for between six and nine criteria.