Treatment and rehabilitation of Long COVID:A scope of the literature. Update October 2023

Summary We identified 12 randomised controlled trials published since early June 2023 that were focused on Long COVID treatment or rehabilitation. Across our six reports produced to date, we have identified and assessed 85 trials published between January 2022 and September 2023. Five of the 12 trials in the current update had a primary focus on treating persistent problems with the sense of smell or taste (olfactory/gustatory dysfunction). Other trials focused on individuals with multiple or non-specific Long COVID symptoms (n=2); respiratory health and physical fitness (n=2); cognitive dysfunction (n=1); and fatigue (n=1). One trial focused on cardiac dysfunction in individuals with persistent cognitive symptoms (n=1). One trial was rated positively for 12 out of the 13 quality criteria that we assessed. Three trials met 10 criteria and eight trials gained a positive rating for either eight or nine of the criteria.