Obireddy, S.R. and Lai, W.-F. orcid.org/0000-0003-0585-6396 (2024) Advances in preclinical approaches for intravesical therapy of bladder cancer. Current Opinion in Urology, 34 (4). pp. 227-235. ISSN 0963-0643
Abstract
Purpose of review
The purpose of this review is to explore new strategies to treat bladder cancer. This article addresses challenges and opportunities in intravesical therapy of bladder cancer.
Recent findings
The review examines the latest advances in the development of preclinical approaches for intravesical therapy of bladder cancer. It discusses strategies to improve drug delivery efficiency by using synthesized diverse carriers. Immunotherapy with protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride has been shown to be more effective than intravesical Bacillus Calmette-Guerin. Novel drug delivery systems such the urinary drug-disposing strategy and intravesical nanoparticle formulations improve the drug delivery efficiency while minimizing adverse reactions. Innovative imaging techniques using near-infrared fluorescence probes and multifunctional nano-transformers enable real-time detection and targeted therapy in bladder cancer treatment.
Summary
Treatment of bladder cancer is clinically challenging. However, recent progress in drug delivery technologies shows promise. Optimizing these technologies helps improve patient outcomes, and facilitates clinical translation of different treatment modalities.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This item is protected by copyright. This is an author produced version of an article published in Current Opinion in Urology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Medical Biotechnology; Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Urologic Diseases; Cancer; Bioengineering; Biotechnology; Nanotechnology; Pharmaceuticals; Cancer; Urinary Bladder Neoplasms; Humans; Administration, Intravesical; Drug Delivery Systems; Immunotherapy; Antineoplastic Agents; Animals; Nanoparticles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Sep 2024 13:25 |
Last Modified: | 11 Sep 2024 13:27 |
Published Version: | https://journals.lww.com/co-urology/fulltext/2024/... |
Status: | Published |
Publisher: | Lippincott, Williams & Wilkins |
Identification Number: | 10.1097/mou.0000000000001186 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:217083 |
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Filename: Advances in preclinical approaches for intravesical therapy of bladder cancer.pdf
