Thet, N.T. orcid.org/0000-0002-3853-1486, Patenall, B.L., Short, R.D. orcid.org/0000-0001-9173-1180 et al. (1 more author) (2024) On-demand release of silver from composite hydrogel by cold atmospheric plasma jet for wound infection control. Applied Physics Letters, 124 (21). 211902. ISSN 0003-6951
Abstract
Silver is an antimicrobial commonly used within wound care chiefly in advanced dressings or in a topical cream form, such as silver sulfadiazine (SSD). Although silver is effective at controlling the growth of many common wound bacteria, it can be cytotoxic and can build up in tissue, stalling the healing process. Here, we demonstrate the development of an on-demand release system for delivery of silver from a composite hydrogel comprising sodium polyacrylate particles dispersed in a cryo-crosslinked polyvinyl alcohol carrier gel. Application of cold atmospheric plasma (CAP) jet to the silver loaded hydrogel resulted in controlled release of silver. This release is thought to occur due to the formation of nitrous acids in the hydrogel by the CAP, resulting in protonation of carboxylate groups in the hydrogel and subsequent gel de-swelling due to the reduction in interchain charge repulsion. The location of silver within the sodium polyacrylate particles was probed using scanning electron microscopy and EDX imaging. The released silver inhibited the growth of Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus and significantly reduced the viable cell count of the P. aeruginosa biofilm.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | Nanoparticle; Transition metals; Hydrogels; Polymers; Plasmas; Antimicrobials; Diseases and conditions; Bacteria; Biofilms; Scanning electron microscopy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 Aug 2024 11:37 |
Last Modified: | 30 Aug 2024 11:37 |
Status: | Published |
Publisher: | AIP Publishing |
Refereed: | Yes |
Identification Number: | 10.1063/5.0206812 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216595 |