van den Bogaard, E.H., Elias, P.M., Goleva, E. et al. (5 more authors) (2023) Targeting skin barrier function in atopic dermatitis. The Journal of Allergy and Clinical Immunology: In Practice, 11 (5). pp. 1335-1346. ISSN 2213-2198
Abstract
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of skin barrier dysfunction is complex and rooted in genetic mutations, interactions between the immune pathway activation and epithelial cells, altered host defense mechanisms, as well as environmental influences that cause epithelial cell activation and release of alarmins (such as thymic stromal lymphopoietin) that can activate the type 2 immune pathway, including generation of interleukins 4 and 13, which induces defects in the skin barrier and increased allergic inflammation. These inflammatory pathways are further influenced by environmental factors including the microbiome (especially Staphylococcus aureus), air pollution, stress, and other factors. As such, AD is a syndrome involving multiple phenotypes, all of which have in common skin barrier dysfunction as a key contributing factor. Understanding mechanisms leading to skin barrier dysfunction in AD is pointing to the development of new topical and systemic treatments in AD that helps keep skin borders secure and effectively treat the disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 American Academy of Allergy, Asthma & Immunology |
Keywords: | Aryl hydrocarbon receptor; Atopic dermatitis; Barrier repair; Dupilumab; Eczema; Interleukin-13; Interleukin-4; Moisturizer; Staphylococcus aureus; Humans; Dermatitis, Atopic; Skin; Cytokines; Inflammation; Thymic Stromal Lymphopoietin |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Aug 2024 13:13 |
Last Modified: | 29 Aug 2024 13:15 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.jaip.2023.02.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216572 |