Duan, M.Q., Byers, R.A. orcid.org/0000-0001-8582-9325, Danby, S.G. orcid.org/0000-0001-7363-140X et al. (8 more authors) (2023) Potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment. Biomedical Optics Express, 14 (8). pp. 4126-4136. ISSN 2156-7085
Abstract
Crisaborole 2% ointment is a non-steroidal treatment for mild-moderate atopic dermatitis (AD) and may produce fewer adverse effects than topical corticosteroids (TCS). We used PS-OCT to quantify dermal collagen at baseline and after 29 days of treatment with crisaborole and betamethasone valerate (BMV), in 32 subjects. PS-OCT detected a mean increase 1 × 10-6, 95% CI (6.3, 1.37) × 10-6 in dermal birefringence following TCS use (p < 0.0001, ad-hoc, not powered), whereas a change of -4 × 10-6, 95% CI (-32, 24) × 10-6 was detected for crisaborole (p = 0.77, ad-hoc, not powered). These results could suggest a differential effect on dermal collagen between the two compounds. PS-OCT may thus find an important role in safety assessment of novel AD treatment’ and larger trials are warranted.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Journal © 2023. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Electronic and Electrical Engineering (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number LEO FOUNDATION LF-OC-21-000723 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Aug 2024 10:00 |
Last Modified: | 23 Aug 2024 10:00 |
Published Version: | http://dx.doi.org/10.1364/boe.494464 |
Status: | Published |
Publisher: | Optica Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1364/boe.494464 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216385 |