Martinez, Karina, Agirre, Jon orcid.org/0000-0002-1086-0253, Akune, Yukie et al. (33 more authors) (2024) Functional implications of glycans and their curation:insights from the workshop held at the 16th Annual International Biocuration Conference in Padua, Italy. Database. baae073. ISSN 1758-0463
Abstract
Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture disease and phenotype information focus primarily on the macromolecules within the central dogma of molecular biology (DNA, RNA, proteins). To gain a better understanding of organisms, there is a need to capture the functional impact of glycans and glycosylation on biological processes. A workshop titled "Functional impact of glycans and their curation" was held in conjunction with the 16th Annual International Biocuration Conference to discuss ongoing worldwide activities related to glycan function curation. This workshop brought together subject matter experts, tool developers, and biocurators from over 20 projects and bioinformatics resources. Participants discussed four key topics for each of their resources: (i) how they curate glycan function-related data from publications and other sources, (ii) what type of data they would like to acquire, (iii) what data they currently have, and (iv) what standards they use. Their answers contributed input that provided a comprehensive overview of state-of-the-art glycan function curation and annotations. This report summarizes the outcome of discussions, including potential solutions and areas where curators, data wranglers, and text mining experts can collaborate to address current gaps in glycan and glycosylation annotations, leveraging each other's work to improve their respective resources and encourage impactful data sharing among resources. Database URL: https://wiki.glygen.org/Glycan_Function_Workshop_2023.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2024. Published by Oxford University Press. |
Keywords: | Polysaccharides/metabolism,Humans,Data Curation/methods,Glycosylation,Italy,Biocuration |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number THE ROYAL SOCIETY URF\R\221006 |
Depositing User: | Pure (York) |
Date Deposited: | 21 Aug 2024 09:10 |
Last Modified: | 16 Oct 2024 20:05 |
Published Version: | https://doi.org/10.1093/database/baae073 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1093/database/baae073 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216325 |
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Filename: baae073.pdf
Description: Functional implications of glycans and their curation: insights from the workshop held at the 16th Annual International Biocuration Conference in Padua, Italy
Licence: CC-BY 2.5