Martinez, J., Ingram, N., Kapur, N. et al. (2 more authors) (2024) Vesicle-based formulations for pain treatment: a narrative review. PAIN Reports, 9 (6). e1196. ISSN 2471-2531
Abstract
Pain, a complex and debilitating condition, necessitates innovative therapeutic strategies to alleviate suffering and enhance patients' quality of life. Vesicular systems hold the potential to enhance precision of drug localisation and release, prolong the duration of therapeutic action and mitigate adverse events associated with long-term pharmacotherapy. This review critically assesses the current state-of-the-art in vesicle-based formulations (liposomes, polymersomes, ethosomes, and niosomes) for pain management applications. We highlight formulation engineering strategies used to optimise drug pharmacokinetics, present preclinical findings of experimental delivery systems, and discuss the clinical evidence for the benefits of clinically approved formulations. We present the challenges and outlook for future improvements in long-acting anaesthetic and analgesic formulation development.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Pain relief, Vesicle-based technologies, Drug delivery, Analgesics, Liposomes, Polymersomes, Ethosomes, Niosomes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Physical Chemistry (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 219420/Z/19/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Aug 2024 08:39 |
Last Modified: | 29 Oct 2024 15:38 |
Status: | Published |
Publisher: | Lippincott, Williams & Wilkins |
Identification Number: | 10.1097/PR9.0000000000001196 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216162 |
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