Liu, C., Li, Y., Li, W. et al. (10 more authors) (2024) LSPR-enhanced photoresponsive antibacterial efficiency of Bi/MoS2-loaded fibrin gel for management of diabetic wounds. International Journal of Biological Macromolecules, 277 (3). 134430. ISSN 0141-8130
Abstract
Chronic diabetic wounds present formidable challenges, marked by uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The evolving landscape of photo-responsive antibacterial therapy holds great promise in addressing these multifaceted issues, with a particular focus on leveraging the distinctive properties of 2D heterojunction materials. In this investigation, we engineered composite sprayed hydrogels, seamlessly integrating Bi/MoS2 nano-heterojunctions. Capitalizing on the synergistic interplay between photocatalytic antibacterial and photothermal antibacterial mechanisms, the Bi/MoS2 heterojunction, guided by its localized surface plasmon resonance, demonstrated outstanding antibacterial efficacy within a mere 10-minute exposure to 808 nm near-infrared light. This accelerated sterilization both in vitro and in vivo, consequently expediting wound healing. The sprayed composite gel not only furnishes protective shielding for skin tissues but also fosters endothelial cell proliferation, vascularization, and angiogenesis. This safe and ultrafast sterilizing hydrogel presents immense potential for application in antimicrobial dressings, thereby offering a promising avenue for diabetic wound healing.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2024 Elsevier. This is an author produced version of an article accepted for publication in International Journal of Biological Macromolecules. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Nano-heterojunctions; Antimicrobial; Near-infrared light; Diabetic wound repair |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Funding Information: | Funder Grant number Royal Society IEC\NSFC\191344 |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Aug 2024 14:37 |
Last Modified: | 15 Aug 2024 11:09 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijbiomac.2024.134430 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216119 |
Download
Filename: IJBIOMAC-D-24-10210_R1.pdf
