Shiha, M.G. orcid.org/0000-0002-2713-8355, Yusuf, A. and Sanders, D.S. (2024) Role of endoscopy in the diagnosis of coeliac disease: a narrative review. Translational Gastroenterology and Hepatology, 9. 51. ISSN 2415-1289
Abstract
BACKGROUND AND OBJECTIVE: Coeliac disease (CD) is a common autoimmune disorder triggered by gluten consumption in genetically predisposed individuals. CD is characterised by chronic inflammation in the small bowel mucosa with an influx of lymphocytes, followed by crypt hyperplasia and villous atrophy. The gold standard test to diagnose CD is endoscopy with duodenal biopsies. However, variations in practice between endoscopists can lead to missed diagnoses. This review aims to discuss the role of endoscopy in the diagnosis of CD, highlighting the performance measures of endoscopy in CD and the advancement in endoscopic techniques for the optical diagnosis of villous atrophy. METHODS: We searched PubMed and Google Scholar from their inception to December 2023 for relevant articles on the role of endoscopy in CD. Two authors reviewed these references, and relevant studies were included in the discussion section of this review. KEY CONTENT AND FINDINGS: We provide an up-to-date assessment of the diagnostic accuracy of endoscopic markers of CD and the performance of enhanced endoscopic imaging to identify villous atrophy during endoscopy. We propose a set of benchmarks for endoscopy in CD and discuss the potential role of artificial intelligence (AI) in the endoscopic diagnosis of CD. CONCLUSIONS: Performing high-quality endoscopy and identifying strategies to reduce inter-endoscopist variations may reduce missed diagnoses. Adopting advanced endoscopic techniques and embracing new technologies such as AI could enhance diagnostic accuracy and improve patient care.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Coeliac disease (CD); biopsy; endoscopy; transglutaminases |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Aug 2024 11:02 |
Last Modified: | 13 Aug 2024 11:02 |
Published Version: | http://dx.doi.org/10.21037/tgh-23-122 |
Status: | Published |
Publisher: | AME Publishing Company |
Refereed: | Yes |
Identification Number: | 10.21037/tgh-23-122 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216027 |
Download
Filename: Role of endoscopy in the diagnosis of coeliac disease a narrative review. .pdf
Licence: CC-BY-NC-ND 4.0