Urwin, L. orcid.org/0000-0002-7667-8630, Savva, O. and Corrigan, R.M. orcid.org/0000-0002-6031-1148 (2024) Microbial Primer: what is the stringent response and how does it allow bacteria to survive stress? Microbiology, 170 (7). 001483. ISSN 1350-0872
Abstract
The stringent response is a conserved bacterial stress response that allows bacteria to alter their activity and survive under nutrient-limiting conditions. Activation of the stringent response is characterized by the production of intracellular signalling molecules, collectively termed (p)ppGpp, which interact with multiple targets inside bacterial cells. Together, these interactions induce a slow growth phenotype to aid bacterial survival by altering the transcriptomic profile of the cell, inhibiting ribosome biosynthesis and targeting enzymes involved in other key metabolic processes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | ppGpp; stress; stringent response; Stress, Physiological; Bacteria; Gene Expression Regulation, Bacterial; Bacterial Physiological Phenomena; Signal Transduction; Microbial Viability; Guanosine Pentaphosphate; Bacterial Proteins |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 104110/Z/14/A |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Aug 2024 14:50 |
Last Modified: | 12 Aug 2024 14:50 |
Status: | Published |
Publisher: | Microbiology Society |
Refereed: | Yes |
Identification Number: | 10.1099/mic.0.001483 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:216002 |