Brown, B., Ward, A., Fazili, Z. et al. (2 more authors) (2021) Application of UV dissolution imaging to pharmaceutical systems. Advanced Drug Delivery Reviews, 177. 113949. ISSN 0169-409X
Abstract
UV–vis spectrometry is widely used in the pharmaceutical sciences for compound quantification, alone or in conjunction with separation techniques, due to most drug entities possessing a chromophore absorbing light in the range 190–800 nm. UV dissolution imaging, the scope of this review, generates spatially and temporally resolved absorbance maps by exploiting the UV absorbance of the analyte. This review aims to give an introduction to UV dissolution imaging and its use in the determination of intrinsic dissolution rates and drug release from whole dosage forms. Applications of UV imaging to non-oral formulations have started to emerge and are reviewed together with the possibility of utilizing UV imaging for physical chemical characterisation of drug substances. The benefits of imaging drug diffusion and transport processes are also discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This is an author produced version of an article published in Advanced Drug Delivery Reviews. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Diffusion; Dissolution testing; Intrinsic dissolution rate; In-vitro release; Parenterals; UV imaging |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Pharmacy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2024 13:11 |
Last Modified: | 14 Aug 2024 13:29 |
Published Version: | https://www.sciencedirect.com/science/article/pii/... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.addr.2021.113949 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215968 |
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