Brown, B., Fazili, Z., Ward, A. et al. (4 more authors) (2021) An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging. Journal of Drug Delivery Science and Technology, 61. 102143. ISSN 1773-2247
Abstract
The purpose of this study was to characterize compact surfaces (surface roughness) and study its potential importance to the intrinsic dissolution rate (IDR) as determined by dissolution imaging. To this end, the effect of varying compaction pressures and the use of two stainless-steel surfaces with different textures/roughness on the intrinsic dissolution were investigated. Ketoprofen (KET), paracetamol (PAR) and ibuprofen (IBU) were compacted and a focus variation microscope used to determine the surface topology of the compacts. IDR determination was conducted using a surface dissolution imaging apparatus with the flow-through set up in phosphate buffer at pH 7.2 and at 37 °C. The results indicated a general decrease in the surface area of the drug compacts with an increase in compaction force (p values < 0.05 for IBU and PAR but not KET). This change in surface area was measured using the Sdr parameter, which can be defined as the developed interfacial area. The smoother stainless-steel plate insert produced significantly smoother compacts for KET (Sdr decreased from 0.30% to 0.07%). However, PAR and IBU compacts showed an increase in their Sdr values from 3.94% to 17.90% and from 0.60% to 0.83%, respectively, suggesting the changes in surface properties to be drug specific relating to poor compaction properties and elasticity. The dissolution studies suggested that low compaction forces were not suitable for PAR. Overall changes in the surface topology did not have a significant effect on the obtained IDR values.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This is an author produced version of an article published in the Journal of Drug Delivery Science and Technology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Ketoprofen; Paracetamol; Ibuprofen; Intrinsic dissolution rate; UV-Imaging; Focus variation microscopy; Dissolution imaging |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Pharmacy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2024 12:51 |
Last Modified: | 13 Aug 2024 12:51 |
Published Version: | https://www.sciencedirect.com/science/article/pii/... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jddst.2020.102143 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215967 |