Alshiyab, D. orcid.org/0000-0003-0244-0221, Ba-shammakh, S.A. orcid.org/0000-0003-1927-8507, Al-Fakih, A. orcid.org/0009-0009-4810-0987 et al. (6 more authors) (2024) Efficacy and safety of 308-nm Excimer lamp combined with Tacrolimus 0.1% ointment vs Tacrolimus 0.1% ointment as monotherapy in treating children with limited vitiligo: a randomized controlled trial. Journal of Dermatological Treatment, 35 (1). 2296851. ISSN 0954-6634
Abstract
Objective: This study aims to assess the efficacy and safety of combining the 308-nm Excimer lamp with Tacrolimus 0.1% ointment, compared to Tacrolimus 0.1% ointment monotherapy, for treating pediatric vitiligo involving less than 10% of the body surface area.
Methods: Fifty pediatric patients with vitiligo were randomly assigned to two groups. Group A received Tacrolimus 0.1% ointment twice daily and Excimer light at 308-nm twice weekly, while Group B received Tacrolimus 0.1% ointment alone, administered twice daily. Repigmentation percentages were evaluated after 30, 90, and 180 days using the rule of nine.
Results: Group A exhibited a significant improvement in repigmentation, increasing from 10% after one month to 65% after six months. In contrast, Group B observed an increase from 10% to 30% over the same timeframe. The efficacy of the treatment was significantly higher in Group A at both the 3-month and 6-month follow-up points (p-value <.001). Moreover, Group A achieved notably higher repigmentation rates in the face, trunk, and lower limbs.
Conclusion: The combination of Tacrolimus and the 308-nm excimer lamp yielded superior repigmentation results compared to Tacrolimus monotherapy in pediatric vitiligo patients. This combined approach may offer an effective new treatment protocol for pediatric vitiligo.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 the author(s). Published with license by Taylor & Francis group, LLC. This is an open access article distributed under the terms of the creative commons attribution-non commercial license (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. the terms on which this article has been published allow the posting of the accepted manuscript in a repository by the author(s) or with their consent. |
Keywords: | Excimer light; The study is registered at clinicaltrials.gov under the identifier NCT06035614; pediatric; treatment; vitiligo; Child; Humans; Combined Modality Therapy; Ointments; Tacrolimus; Treatment Outcome; Vitiligo |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Aug 2024 10:47 |
Last Modified: | 08 Aug 2024 10:47 |
Status: | Published |
Publisher: | Informa UK Limited |
Refereed: | Yes |
Identification Number: | 10.1080/09546634.2023.2296851 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215783 |