Dynamics of cortical contrast adaptation predict perception of signals in noise

Abstract

Neurons throughout the sensory pathway adapt their responses depending on the statistical structure of the sensory environment. Contrast gain control is a form of adaptation in the auditory cortex, but it is unclear whether the dynamics of gain control reflect efficient adaptation, and whether they shape behavioral perception. Here, we trained mice to detect a target presented in background noise shortly after a change in the contrast of the background. The observed changes in cortical gain and behavioral detection followed the dynamics of a normative model of efficient contrast gain control; specifically, target detection and sensitivity improved slowly in low contrast, but degraded rapidly in high contrast. Auditory cortex was required for this task, and cortical responses were not only similarly affected by contrast but predicted variability in behavioral performance. Combined, our results demonstrate that dynamic gain adaptation supports efficient coding in auditory cortex and predicts the perception of sounds in noise.

Metadata

Item Type:	Article
Authors/Creators:	Angeloni, C.F. Młynarski, W. Piasini, E. https://orcid.org/0000-0003-0384-7699 Williams, A.M. Wood, K.C. https://orcid.org/0000-0002-5520-5025 Garami, L. Hermundstad, A.M. https://orcid.org/0000-0002-0377-0516 Geffen, M.N. https://orcid.org/0000-0003-3022-2993
Copyright, Publisher and Additional Information:	© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/.
Keywords:	Animals; Mice; Auditory Perception; Noise; Sound; Auditory Cortex; Adaptation, Physiological; Acoustic Stimulation
Dates:	Published: 9 August 2023 Published (online): 9 August 2023 Accepted: 27 July 2023
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	08 Aug 2024 13:12
Last Modified:	08 Aug 2024 13:12
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	10.1038/s41467-023-40477-6
Related URLs:	PubMed URL Dataset
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:215764

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Dynamics of cortical contrast adaptation predict perception of signals in noise

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Dynamics of cortical contrast adaptation predict perception of signals in noise

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