Noble, Amanda R, Akkad, Saeed orcid.org/0000-0002-7271-0496, Yates, Nicholas D J et al. (3 more authors) (2024) Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer. RSC Advances. pp. 23796-23801. ISSN 2046-2069
Abstract
Prostate cancer is the most common cancer in men in the UK with over 50 000 new cases diagnosed each year and although therapeutic advances in surgery, anti-androgens, radio- and chemotherapy have increased survival rates, there still remains a need for new treatments to combat the most aggressive forms of the disease. Gene therapy offers promise as an alternative approach but is reliant on selective targeting to the cancer cell surface. Herein we describe the novel construction of a prostate specific membrane antigen (PSMA) binding bioconjugate-polyplex, based on a glutamate-urea peptide scaffold using 'click' chemistry, which we demonstrate is capable of targeted delivery of a GFP gene to PSMA overexpressing prostate cancer cells, and therefore may have potential future application as part of a prostate cancer gene delivery therapy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION 101044024 |
Depositing User: | Pure (York) |
Date Deposited: | 02 Aug 2024 08:20 |
Last Modified: | 01 Apr 2025 23:11 |
Published Version: | https://doi.org/10.1039/d4ra03640a |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/d4ra03640a |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215656 |
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Description: Towards a ‘clicked’ PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer
Licence: CC-BY 2.5