Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

Abstract

Cleaning and coating processes as well as biocompatibility of gyroid commercially pure titanium (Cp-Ti) biomedical implants using the laser powder bed fusion (L-PBF) technology were analyzed. Etching time for cleaning of gyroid Cp-Ti biomedical implants were determined to remove non-melted particles from the surface. Nano hydroxyapatite (nHA) and polylactic acid (PLA) composite coating on the gyroid Cp-Ti implants via dip coating were optimized. Dip coating’s withdrawal speed also, the amount of nHA:PLA and viscosity effects of composite were evaluated. 1000 mm/min withdrawal speed prevented clogging of the pores. In addition, silk fibroin was coated on gyroid Cp-Ti implants with electro deposition method. Optimum coating thicknesses were achieved. Biocompatibility after PLA:nHA and silk fibroin were studied. Gyroid and solid Cp-Ti presented 3% and 1% mass loss after a minute of HF/HNO3 etching. The three-minute etching protocol led to the highest micro pit width formation on the surfaces. 70:30 PLA:nHA and silk fibroin established crack-free coatings on gyroid Cp-Ti surfaces. MTT, live-dead cell assay revealed good biocompatibility after coating.

Metadata

Item Type:	Article
Authors/Creators:	Depboylu, F.N. Taşkonak, B. Korkusuz, P. Yasa, E. https://orcid.org/0000-0001-5443-3598 Ajiteru, O. Choi, K.Y. Park, C.H. Poyraz, Ö https://orcid.org/0000-0001-9892-5738 Popa, A.-A. Korkusuz, F.
Copyright, Publisher and Additional Information:	© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Chemical etching; Composite; Silk-fibroin; Dip coating; Electro-deposition technique; Cell viability
Dates:	Published: December 2024 Published (online): 5 July 2024 Accepted: 18 June 2024 Submitted: 26 March 2024
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > University of Sheffield Research Centres and Institutes > AMRC with Boeing (Sheffield) The University of Sheffield > Advanced Manufacturing Institute (Sheffield) > AMRC with Boeing (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	06 Aug 2024 14:34
Last Modified:	06 Jan 2025 12:08
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	10.1007/s42247-024-00774-2
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:215533

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Cleaning and coating procedures determine biological properties of gyroid porous titanium implants

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